Select therapeutic strategy:

Clearance machinery

Neuroprotection/neuromodulation

Mitochondrial dysfunction

Chaperone-related polyQ protein turnover

Inhibition of polyQ protein aggregation

polyQ protein turnover enhancement

polyQ protein turnover enhancement (UPS)

polyQ protein turnover enhancement (autophagy)

Environmental enrichment-induced neuroprotection

Neurogenesis promotion

Neurotransmitter activity regulation

Neurotrophic factor-induced neuroprotection

Transglutaminase inhibition-induced neuroprotection

Anti-oxidation

Ca2+: intracellular level modulation

Energy metabolism

Protection from excitotoxicity

Downregulation of polyQ protein expression

Neutralization of polyQ protein toxicity

Transcription regulation / Chromatin remodeling

Cell therapy

Diabetes

Inflammatory pathways

Metabolic improvement

Others

Sleep/wake cycles regulation

Apoptosis

PolyQ protein

Other targets